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When NNMT runs hot, less precursor gets recycled back into NAD+

Carlotto A, Hogsett VL, Maiorini EM, Razulis JG, Sonis ST

When MPTP damages nigral dopaminergic neurons, the cellular debris and inflammatory mediators released by these neurons can further activate microglia, leading to a substantial release of inflammatory factors and the formation of a self-reinforcing vicious cycle